Path of Exile is a dark fantasy themed free to play MMORPG game that shares many similarities with dungeon-crawling titles such as the popular Diablo series as well as games like Baldurs Gate. The game is based on the world of Wraeclast, a land corrupted by dark forces that have bought about the apocalypse. Players take the role of an exile, driven from their homeland and forced to fight to stay alive.

The game includes a revolutionary skill system that sets it apart from other online titles. Players are not restricted to classes or abilities, instead skills are displayed in the form of Skill Gems. These gems come in many variations such as Support Gems and Active Gems. These gems will give the player access to a certain skill, that will level along with the player. As the ability levels, it gains more effects and strength, it is even possible for players to make a living by leveling skills and then selling them onto other players. Each ability is also customizable via Sockets, a player can equip gems to sockets along with other gems for added effect. This allows for totally unique abilities allowing players to create deadly spells such as a trap that binds the target, while poisoning them, before exploding and releasing a huge wave of fire.

Path of Exile features mostly instanced areas, much like the popular dungeon crawler titles of today. However, each and every instance can be randomized with an almost infinite amount of possibilities. The same engine also randomizes the loot, monsters and challenges within the instance. This allows for a large amount of re-playability, giving players a unique experience each and every time.

The company has announced that the game will feature an item-mall but they specifically called it "ethical microtransactions". Players will be able to purchase stuff such as name changes, server transfers, PvP taunts and other aesthetic items, none of which will give anyone an advantage in combat.